25 years experience of teaching Maths and Sciences to primary, secondary and tertiary level students has inspired me to develop of series of self-directed learning resources.
The subject matter for Maths, Chemistry, Biology and Physics is distilled into memorable infographics, annotated with keywords/phrases. The infographic book has an accompanying compendium of Q&A, compiled from a large dataset of past exam questions. Variations of the same underlying generic questions are grouped together, followed by template answers, which detail the keywords and phrases for which examiners award marks.
Academic Biomedical Research History
Yorkshire Cancer Research Fellow, Virology Group, Department of Biochemistry, University of Leeds, 2002-2008.
My work demonstrated that adenovirus causes alteration of the architecture of structures, within the nucleii of infected cells, known as 'Cajal bodies' Journal of Virology 2010. Further investigation revealed that the rearrangement of Cajal bodies is essential for the assembly of new infectious viruses. My research suggests that disabling the function of Cajal bodies could prove a useful target strategy to prevent the spread of viruses.
British Heart Foundation Research Fellow, Deparment of Cardiovascular Research, University of Leeds, 2001-2002.
High blood pressure causes injury to blood vessels and is a major risk factor for coronary artery disease. I investigated responses of human cardiac cells to hormones that control vascular tone, to mimic the effects of high blood pressure in vivo. Using a state-of-the-art cell sorter, I developed a technique to allow the controlled addition of hormones to cardiac cells channeled in a fluid stream. Cells that responded to the various stimuli were isolated from the non-responding cells. Biological changes in the two cell populations were compared.
British Heart Foundation PhD Student, Dept of Biochemistry & Molecular Biology, Royal Free & University College London, 1996-2000.
The progression of coronary artery disease to cardiac arrest and stroke and the transformation of cancers from benign to malignant are both dependent upon the formation of new capillary blood vessels. I proposed and carried out an investigation into the role of blood clotting proteins in the formation of new capillaries. I devised a cellular model system that continues to be used as a standard technique. My work showed the involvement of a specific protein called tissue factor, in the process. I cloned the tissue factor protein and created mutations to enable me to establish it's structurally important features. I was awarded a PhD in Biochemistry for my contribution to research in this area. I presented my work at the First International Conference on Thrombosis and Haemostasis Issues in Cancer Biology, Bergamo, Italy, 2001, at a time when a connection between the development of arterial disease with underlying tumours was first becoming appreciated in the medical world.
JRC Research Assistant, Cardiovascular Group, Dept of Medicine, King's College School of Medicine & Dentistry, 1992-1996.
I was very fortunate to begin my journey into scientific research within a distinguished team headed by the (then) BHF Professor of Cardiovascular Research John F. Martin, in collaboration with Dr Jorge D. Erusalimsky and Prof Ian Zachary, both former researchers at the Imperial Cancer Research Fund laboratories, London, home of the research team of Prof. Sir Paul Nurse, winner of the 2001 Nobel Prize for Medicine.
I developed an in vitro model system of blood stem cell maturation, using a magnetic separation technique to purify blood stem cells from human umbilical cord blood. We used this model system to study the biological mechanisms involved in the decision of stem cells to mature along particular lineages. The cell signalling mechanisms that control the fate of stem cells in commitment to either the red cell or the platelet pathway were investigated. The model system was also used to investigate platelet fragmentation in collaborative studies with Prof Steve P. Watson in the Dept of Pharmacology, Oxford University and also by Dr Elisabeth Cramer, INSERM, France, published in Blood, 1997.